This research aimed (1) to study the level of development factors of Rajabhat Universities in the northeastern region affecting an entrepreneurial university; (2) to study the level of characteristics of entrepreneurial universities in the Northeastern region; (3) to study the factors of development of Rajabhat University in the Northeastern region that affect to being an entrepreneurial university; and (4) to propose a model for the development of Rajabhat University in the northeastern region into an entrepreneurial university. The population of the study was the administrators and personnel of the Rajabhat University of Thailand. The sample size of the study was three hundred and sixty respondents. The statistical analysis of the research was done using descriptive analysis and multiple regression analyses. The results showed that (1) the mean values of development factors variable and characteristics of an entrepreneurial university were high; (2) development factors that influenced the characteristics of an entrepreneurial university were organizational strategy and structure, system, shared value, politics and policies, economics, and environment; and (3) when arranging the importance of development factors that clearly affected the university, it was found that organizational strategy was the most important, followed by shared values, systems, and organizational politics and policies. This study suggests that the administrators of Rajabhat Universities of Thailand should focus on the development factors that are of high importance such as corporate strategy, shared values, politics, and organizational policies. This will eventually lead to a successful development towards an entrepreneurial university in the future.    Received: 7 November 2021 / Accepted: 7 January 2022 / Published: 5 March 2022