Background: With the increasing prevalence of diabetes mellitus (DM), vitamin D (vit D) deficiency and vascular calcification is frequently observed in DM and is an indicator of diabetic peripheral vascular disease with variable implications. Due to the current limited understanding, this research was initiated. Aims and objective was to critically assess the prevalence and severity of vitamin D deficiency in patients with diabetic foot infection, the association between vascular calcification and vitamin D deficiency and effect on healing in diabetic foot patient with and without vitamin D deficiency.Methods: This observational study was conducted on 50 patients with diabetes mellitus. A detailed clinical history was recorded. Infection was confirmed by culture positivity and Doppler was used to detect vascular calcification. A follow-up for 3 weeks was done after which wound healing rate was assessed by change in wound surface area. Data was analyzed by Chi-square test and multivariate regression analysis.Results: 58% patients were diagnosed with vitamin D deficiency. 40% of patients found to have VC associated with DM. 100 % association of VC was found in patients with severe vitamin D deficiency. Vitamin D deficiency significantly correlated with vascular calcification (p=0.0001). A significant difference was observed in wound healing between the patients with and without vitamin D deficiency i.e.  3.14±2.04mm.sq and 4.36±1.39mm.sq.Conclusions: This study opens up an issue of recognizing vitamin D deficiency as a possible risk factor for diabetic foot infections and suggests the need for vitamin D supplementation.

Background: Urolithiasis i.e. stone firming disease in the urinary passages is one of the frequently encountered diseases in man. Perhaps the disease is as ancient as the man himself as has been revealed by the archaeological excavation done in different parts of the world such as in Egypt. Aim: Comparative Study of Malondialdehyde, Superoxide Dismutase and Glutathione Peroxidase in Urolithiasis Patients: A Case Control Study Materials and Methods: The study was carried out in the Department of Biochemistry, Datta Meghe Medical College Nagpur in collaboration with Department of Surgery, Division of Urology and Department of Pharmacology. Results: The urolithiasis patients have shown a marked increase in plasma MDA levels. There was a significant increase in the values of superoxide dismutase in patients suffering from urolithiasis (6.26 ± 0.86 µmol/l RBC lysate) as compared to the normal control values (3.40 ± 1.09 µmol/l RBC lysate) in human volunteers (p<0.01).A significantly decreased value of glutathione peroxidase has been observed in patients suffering from urolithiasis as compared to the control group. Conclusion: Enhanced SOD can reduce the formation of Calcium Oxalate crystals and reduce the damage of renal tubular epithelial cell.

Incisional hernia affects all age groups and involve both male and females. It can be defined as hernia which protrudes through surgical wound which was healed incompletely. Management of incisional hernia requires operative intervention most of the times it may laparoscopic repair with synthetic non-absorbable mesh or open anatomical repair.In partnership with Jawaharlal Nehru Medical College AVBR Hospital (Datta Meghe Institute of Medical Sciences) Sawangi (Meghe), Wardha, Maharashtra, this work was performed in the Department of General Surgery at Datta Meghe Medical College and Shalinitai Meghe Hospital and Research Centre ,Hingna , Nagpur. Over a period of 1 year 59 cases of diagnosed incisional hernia were included.33 males and 26 females were included. The mean age was years. Most common cause of Incisional Hernia (IH)  post-operative wound infection(49.15%). In maximum cases history suggestive of emergency surgery(86.44%).Type of incision suggests maximum cases in midline incision (55.93%) followed by Pffanensteils incision (28.81%).Open mesh hernioplasty was the common procedure (57.62%) ,Lap mesh hernioplasty done in (25.42%)cases and (16.94%) cases were treated by suture repair. There was no evidence of recurrence in laparoscopic repair as open mesh hernioplasty has a recurrence rate of 03.57% and suture repair cases showed 33.33% recurrence.Incisional Hernia and its occurrence can be taken care of by implementing all standard aseptic precautions thereby avoiding chances of infection at the time of primary surgery wherein thorough peritoneal wash, proper techniques of wound closure and use of appropriate antibiotics is recommended. Management of IH with Laparoscopic mesh repair has its own advantage in terms of less hospital stay, negligible rate of recurrence though it is not cost effective at present scenario.

One of the most common problems experienced in surgical practice, which challenges the surgeon and needs the ability to diagnose through knowing the anatomy and pathological process that can occur inside the abdomen, is a mass in the right iliac fossa. The purpose of this research was to examine clinical appearance, differential diagnosis and treatment methods for patients with the right iliac fossa.Study was carried out in the Dept. of General Surgery at Jawaharlal Nehru Medical College and Acharya Vinoba Bhave Rural Hospital, Sawangi (M), Wardha , Maharashtra , between August 2018 to December 2019. 43 patients with signs and symptoms of right iliac fossa mass were studied by taking detailed clinical history, physical examination, and were subjected to various investigations.In the present study appendicular mass constituted 60.46%, appendicular abscess 09.30% ,ileocaecal tuberculosis 06.97 % , carcinoma caecum 13.95 % , intussusseption02.32%. Patients presented with constitutional symptoms like pain , fever , vomiting , weight loss.Appendicular lump remains the most common entity in right iliac fossa mass patients. Ileocaecal tuberculosis is one of the most common differential diagnosis to be considered for pain abdomen evaluation in rural population. Conservative treatment followed by interval appendicectomy remains the main management modality in appendicular lump. The rare cause of mass in right iliac fossa as intussusception should be kept in mind.