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Abstract. Low energy proton capture cross sections on heavy isotopes are necessary for a better understanding of the astrophysical p-process. There are around 35 proton-rich stable isotopes between 74S e and 196Hg which are bypassed by the s- and r- processes. These are commonly referred as p-nuclei whose origin is still not completely understood. In the present study, proton capture reactions are studied on Mo isotopes at astrophysically relevant energies using nuclear modular code TALYS. Astrophysical S factor and reaction rates are also calculated inside a core-collapse supernova. The obtained results are compared with the literature data taken from EXFOR data library. In addition, the effect of different combinations of the nuclear input parameters entering the stellar reaction rate have been investigated.