We examined the cardioprotective effect of nisoldipine against myocardial dysfunction during ischemia and reperfusion in Langendorff perfused rabbit hearts. Nisoldipine was administered to the hearts before 60 minutes of global ischemia. This agent inhibited the increase of end-diastolic pressure during ischemia and also improved the recovery of left ventricular developed pressure and coronary flow during reperfusion in a concentration-dependent manner. The maximal cardioprotective effect was observed in 10(-8) M nisoldipine. The beneficial effect was associated with an increase of coronary flow during reperfusion. Therefore, both the nisoldipine-increased coronary flow during reperfusion and the inhibition of ischemic contracture by nisoldipine seem to play a crucial role in improving myocardial dysfunction of ischemic-reperfused hearts.

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Objectives:The main goal of this study was to inspect the consistency between z-score and the traditional method in the diagnosis of pulmonary artery stenosis in Chinese patients. Methods: 87 normal singleton fetuses and 54 singleton fetuses with pulmonary stenosis (PS) were enrolled in this study. They were performed for standard biometry biparietal diameter (BPD) and femoral diaphysis length (FL) and an assessment of gestation age (GA), and standardised fetal echocardiographic measurements included main pulmonary artery (MPA) and ascending aorta (AO) at end-systole. PA/AO values were calculated to identify whether the pulmonary artery diameter is normal. When the fetal PA/AO values >1, we think it is nomal traditionally. We found a linear regression model between PA, AO and three independent variables (FL,BPD, GA),and the Z-scores were calculated for PA between normal fetuses and PS fetuses from knowledge of FL, BPD and GA. When the z-scores<-2,we think it is positive. At last, The two sets of dates were doing the statistical analysis to inspect the consistency between z-score and the traditional method in the diagnosis of pulmonary artery stenosis, and to compare the advantages of two methods by the fetal cast. Results: In 87 normal fetuses(the PA/AO values >1), the Z-scores for PA from knowledge of FL,BPD and GA >-2.In 54 fetuses with PS(the fetal PA/AO values <1), the numbers of positive fetuses from knowledge of FL, BPD and GA were 27, 32, 24 respectively. The kappa coefficients were 0.5868, 0.6422, 0.6010 respectively, while the 95% CIs were 0.4496∼0,7234,0.5140∼0.7705,0.4576∼0.7445. Conclusions: The z-scores for three independent variables (FL,BPD,GA) permit exact assessment of growth of fetal cardiac structures in fetuses with Smut it was inconsistent with traditional method in diagnosis of PS. Combination of both may help improve clinical prenatal and perinatal exact diagnosis of PS and timely intrauterine intervention. P06.11Comparison of M-mode and 2D-echocardiography in the assessment of fetal ventricular systolic function Objectives: To compare repeatability between left (LV) and right (RV) systolic function, evaluated by M-mode and 2D-echocardiography. Methods: Prospective study including 45 healthy fetuses from low-risk pregnant women evaluated between 18 and 40 weeks of gestation. Biventricular ejection fraction (EF= [(End-diastolic (ED) volume-End-systolic (ES) volume)/ED volume]*100) was evaluated in a transverse 4-chamber view by M-mode as described by Theicholz. Biventricular systolic function was also evaluated in an apical or basal 4-chamber view by 2D-echocardiography, calculating the LV EF (by Simpson monoplane method) and the RV Fractional Area Change (FAC=[(ED Area-ES Area)/ED Area]*100). All measurements were performed for three times by two experienced observers and the mean was considered as a representative final value in each case. The inter-observer repeatability was evaluated by the intraclass correlation coefficient (ICC) and agreement by Bland Altman plots. Results: Table 1 li...

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