Diabetes is emerging as an epidemic disease with an estimation of more than 415 million people already affected, and the figures are expected to grow up to 550 million till 2035 (American Diabetes Association). The various life-threatening complications like nephropathy, neuropathy and retinopathy are usually accomplished with diabetes (Chatterjee et al., 2017). The major cause of renal end-stage disease is diabetic nephropathy which usually developed in the lifetime of 15-40% diabetic patients and is characterised by glomerular atrophy and extracellular matrix accumulation deteriorating kidneys both structurally and functionally (Piccoli et al., 2015;