The present work reports preparation of irbesartan (IBS) loaded nanofibre mats using electrospinning technique. The prepared nanofibres were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, in vitro diffusion and ex vivo skin permeation studies. FTIR studies revealed chemical compatibility of IBS and polyvinyl pyrrolidine (PVP K-30). SEM images confirmed formation of nanofibres wherein IBS existed in amorphous form as revealed by DSC and XRD analyses. The prepared nanofibre mats of IBS were found to be superior to IBS loaded as cast films when analysed for in vitro IBS release and ex vivo skin permeation studies since the flux of IBS loaded nanofibres was 17 times greater than as cast film. The improvement in drug delivery kinetics of IBS loaded nanofibres could be attributed to amorphization with reduction in particle size of IBS, dispersion of IBS at molecular level in PVP matrix and enormous increase in the surface area for IBS release due to nanonization. Thus transdermal patch of IBS loaded nanofibres can be considered as an alternative dosage form in order to improve its biopharmaceutical properties and enhance therapeutic efficacy in hypertension.

Aims: The original phytochemical, UV-Visible, and FTIR Spectral estimation of Tephrosia purpuria root was the subject of this study. Natural phytoconstituents were all found in methanolic extracts from the root of Tephrosia purpuria. Study Design:  Experimental research work. Methodology: Furthermore, using UV Visible spectrophotometer equipment, the extract was scanned in the range of 380 to 900 nm, and the characteristic peaks were identified. Results: The UV-VIS data indicated peaks at 382.70, 413.68, 536.18, 610.37, and 664.61 nm, with absorption values of 2.7930, 2.5932, 0.3114, 0.4185, and 1.5966 respectively. The presence of Natural phytoconstituents is confirmed by FTIR spectra. The findings confirm that this plant has key bioactive elements that are beneficial to our health, indicating that more research is needed. Conclusion: Natural phytoconstituents were all found in methanolic extracts from the root of Tephrosia purpuria.