In addition to weaning, administration of teriparatide followed by denosumab led to remarkable improvement in the patient's symptoms and BMD. Therefore, we regard this method as a promising choice for the treatment of PLO.

Fraser syndrome (FS) involves multiple malformations and has a 25% recurrence risk among siblings. However, these malformations are difficult to detect prenatally, hampering prenatal diagnosis. Here, we describe a fetus with FS diagnosed using ultrasonography. Ultrasonography revealed congenital high airway obstruction syndrome and renal agenesis. Syndactyly of both hands and cryptophthalmos were noted postnatally, and the diagnosis was confirmed by genetic analysis, which showed novel compound heterozygous variants of FREM2.

correct dose at home. This compared to 67%, 29% and 4% respectively for the patients.CONCLUSIONS: This study shows that overall single use pens have less steps and in turn a lower chance of critical handling errors leading to potential dosing errors or safety issues. Following the IFU's, especially when experienced nurses are training both patients and less experienced nurses is essential to a successful treatment cycle. Incorrect instruction, particularly with the multi-dose pens, can lead to patient error and in turn a less favourable outcome.

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