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Background: Coping with cancer plays an important role in cancer survivorship. Especially in young patients, coping is significant because of anxieties regarding fertility, body image, heredity, symptoms of premature menopause, and psychosocial stress. According to previous studies, the group intervention therapy is effective in improving emotional difficulties for breast cancer patients. However, there is few demonstrating the efficacy of group intervention for young breast cancer patients. Methods: Since September 2010, we have conducted a clinical trial of a group intervention, facilitated by breast surgeons, psycho-oncologists, and nurses, for young breast cancer patients who were diagnosed under 35, or 36 years old due to enrolling period, and they had no metastasis. at St Luke's International Hospital (SLIH) in Tokyo, Japan. Each group consisted of 7 to 10 breast cancer patients, who received five weekly sessions. We evaluated the changes in coping strategies, emotional levels, and quality of life (QOL) before, after and 6 month after the group intervention, by using three scales: MAC (Mental Attitude to Cancer) for coping, POMS (Profile of Mood States) for emotional states, and FACT-B (Functional Assessment of Cancer Therapy-Breast) for QOL. MAC scale includes five coping strategies such as Fighting Spirit(FS), Hopelessness(H), Anxious Preoccupation(AP), Anxiety(A), and Fatalism(F). This is an interim report of this clinical trial. Paired T-test was used to statistical evaluation. Results: At this point, 65 young patients finished the group intervention. Complete data were taken from 61 patients for evaluating score changes between before and after the group interventions. POMS and FACT-B score improved statistically (p = 0.004, p = 0.003). Among MAC's five components, Hopelessness and Anxious Preoccupation improved statistically (p<0.01, p<0.001). Discussion: This study suggests that the group intervention is promising to improve emotion states, QOL, and coping strategies for young breast cancer patients. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-11-04.