There are high rates of maternal morbidity including fever, severe anaemia, abortion, still birth, and placental malaria among these women.Consequently, babies can be born with low birth weight due to both prematurity and intrauterine growth retardation [3,10]. However, epidemiological studies of the prevalence and clinical manifestations of P. Falciparum malaria in HIV-infected pregnant women that consider factors such as residential location, CD4 level, viral load, and adherence to intermittent preventive treatment (IPT) and cotrimoxazole regimen, are limited. Nigeria has one of the highest malaria burdens in the world. In 2010,