This study involved developing a matrix-type transdermal therapeutic system comprising of ondansetron hydrochloride with 7:3 ratio of hydrophilic and hydrophobic polymeric combinations using solvent evaporation technique. The effects of permeation enhancers were studied at the concentrations of 2.5% and 5% using essential oils such as menthol oil, eucalyptus oil, clove oil, lemon grass oil and the blend of best volatile oil with Tween 20 dibutyl phthalate and glycerin were used as plasticizers. Formulated patches were evaluated for thickness, folding endurance, drug content, percent moisture absorption, percent moisture loss, tensile strength and water vapour transmission rate. There was no physicalchemical incompatibility between the drug and the polymers. The results of in vitro drug release studies showed that the blend of menthol oil and Tween 20 exhibited maximum release. The optimized formulation was found to be stable during the stability studies. The developed transdermal patches increase the efficacy and improve the bioavailability.
Objective:The main objective of this study was to formulate transdermal gels containing Flurbiprofen microsponges for controlled drug delivery. Methods: Microsponges containing Flurbiprofen and ethylcellulose were prepared by the quasi-emulsion solvent diffusion method. By varying the amount of drug and the polymer, seven batches of microsponges were formulated. Microsponges formed were characterized for surface morphology, thermal behavior, drug content, particle size, X-ray powder diffraction studies and in vitro drug dissolution studies. Results: SEM confirmed the spherical and the porous nature of the microsponges. Formulation F7 showed highest drug content and in vitro drug release of 92.74% at the end of 8 h and all the formulations followed zero order kinetics. Based on the results of drug content and in vitro release studies, formulation F4 was selected as the optimized batch and was incorporated into a carbopol gel base. The in vitro drug release from the microsponge gel was found to be extended over a longer period of time as compared to that from the marketed Flurbiprofen gel. Conclusion: Formulating Flurbiprofen in microsponges facilitated the controlled release of drug for long period of time thus eliminating the need of frequent dosing.
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