Oral squamous cell carcinoma is the most common malignancy of the oral cavity, which is usually preceded by a myriad of oral potentially malignant disorders (OPMDs). In the classification of OPMDs, inherited cancer syndromes (ICSs) were proposed as one of the categories. Inherited cancer syndromes are genetic disorders in which inherited genetic mutation in one or more genes predispose the affected individuals to the development of cancer and may also cause its early onset. Many of these syndromes are caused by mutations in tumor suppressor genes, oncogenes, and genes involved in angiogenesis. General dental practitioners frequently come across OPMDs in their day-to-day practice. It becomes of paramount importance to have knowledge about these rare but prognostically important OPMDs. With this view in mind, in this article, efforts have been made to comprehensively discuss about various ICSs that have higher potential of transformation into oral cancer. The ICSs discussed in this article are xeroderma pigmentosum (XP), ataxia telangiectasia (AT), Bloom syndrome (BS), Fanconi's anemia (FA), and Li-Fraumeni syndrome (LFS), with special emphasis on signs, symptoms, and genetic considerations.

Aim: The purpose of this study was to evaluate the correlation between ABO blood grouping and oral squamous cell carcinoma and to stratify the patients in accordance with the susceptibility as noted. Materials and Methods: This retrospective study included the demographic data of the patients having reported to the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, and Department of Oncology, Yenepoya Medical college and Hospital, Mangalore, Karnataka between January 2017 to December 2021. A total of 161, histopathologically proven oral squamous cell carcinoma patients, between the above time frame of 5 years, were recruited and were analyzed for the study. Results: Patients with A Rh positive blood group had the maximum enrollment (80 patients out of 161) i.e. 49.6%, followed by an equal share of O Rh positive and B Rh positive with 31 each, i.e. 19.25% of each group. Only 8 patients had AB Rh positive blood group, followed by O Rh negative in 6 patients, A Rh negative in 3 patients, and least of B Rh negative blood group in only 2 patients. Conclusion: Our study reflects that as simple as a blood group test, a routine and a regularly followed investigation, can help to sought and stratify the patients, with oral squamous cell carcinoma, who already are on a higher spectrum of falling under the radar of malignancy susceptibility.

The spontaneous regression and remission from malignancy was defined by Everson and Cole as "the partial or complete disappearance of a malignant tumor in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on neoplastic disease."