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Palladium complexes of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane were prepared and characterized with Pd[1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane](2).dba shown to be an effective catalyst for use in the Suzuki and Sonogashira reactions and the alpha-arylation of ketones. Couplings using this versatile complex proceeded in excellent yields under mild conditions.

The Suzuki cross-coupling of aryl boronic acids with aryl halides, including aryl chlorides, proceeds in the phosphonium salt ionic liquid tetradecyltrihexylphosphonium chloride under mild conditions.

The Mitsunobu reaction [1][2][3][4] is widely employed in both condensation and displacement reactions of alcohols with various nucleophiles and normally proceeds with inversion of stereochemistry when chiral secondary alcohols are used. The mechanism of the reaction continues to receive attention and the present view is summarized in Scheme 1. Although the [*] Dr.