Little is known about the effect of foliar nano-nutrients application on pomegranate trees. The experiment was split-plot arranged in a randomized complete block design on some pomegranate cultivars grown at the Experimental Orchard, Faculty of Agriculture, Assiut University, Egypt during three successive season of 2018, 2019 and 2020. The research was to study response of some pomegranate cultivars to foliar spraying with nano-boron and nano-calcium. All the tested applications significantly increased the growth of trees as well as significantly improved the yield and fruit quality and reduced the fruit cracking percentage. Spraying nano-boron plus nano-calcium gave the highest values of growth traits, yield and fruit quality. No significantly differences on all studied traits due to spray nano-boron or nano-calcium singly or in combination. The highest growth traits and yield were recorded on Wonderful followed by Higazy cvs. On other hand, the best fruit quality was detected on Manfalouty pomegranate compared to other studied cultivars.It is recommended to spray Manfalouty, Higazy and Wonderful pomegranate trees with nano-boron or nano-calcium individually or in combination three times to get high yield with good fruit quality.