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A procedure for the time-domain optical characterization of an inclusion in a scattering slab is investigated theoretically and experimentally. The method relies on the measurement of a contrast function, which is defined as the time-dependent relative change in the transmitted signal resulting from the presence of the inclusion. Analytical expressions for the contrast functions of absorptive and diffusive inclusions are obtained through a perturbation solution of the diffusion equation. This procedure is used successfully to determine the optical properties of absorptive, diffusive, and mixed inclusions located at midplane in a scattering slab by use of time-resolved transmittance measurements.

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A technique for discriminating between scattering and absorbing inclusions located in the center of a scattering slab is presented. The technique is based on an empirical model that provides a simple mathematical expression to describe the change in the time-resolved transmission resulting from the presence of an inclusion. Experimental results from various configurations show that the technique allows for proper recognition of the type of an inclusion whether it is scattering or absorbing. This technique is a significant step toward tissue differentiation.

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