Zirconium alloys are used in the nuclear industry due to their low neutron capture cross-section and resistance to corrosion, irradiation and creep. The microstructure of the nuclear fuel components evolves during the manufacturing route and can impact the subsequent processes or the final properties. Thus, numerical modeling of thermo-mechanical manufacturing processes is of interest to understand and master these microstructure evolutions.Numerical modeling of thermo-mechanical manufacturing processes with FORGE® NxT software is applied. These models provide the thermo-mechanical history of the material at each integration point of the finite element (FE) mesh, which can be used to assess locally the continuous dynamic and post-dynamic recrystallization during hot extrusion.Mean-field models were developed in Python and integrated into FORGE® NxT software, to quantify the microstructure evolution at the macro-scale of the component. Full-field models (DIGIMU® software1) were also developed for considering microstructural heterogeneities and the influence of initial microstructure at the mesoscopic scale while improving the mean-field equations by homogenization.After validation based on experimental results, these two recrystallization models provide complementary information to optimize the process parameters at the macro-scale and to better understand mesoscopic scale phenomena, such as:• At the macro-scale: influence of hot extrusion parameters on the continuous dynamic and post-dynamic recrystallization of Zircaloy-4.• At the meso-scale: influence of the initial microstructure on the recrystallization phenomena with improved precision. Indeed, the topology of the microstructure is predicted and not only the mean values/distributions of the state variables.