The infrared capabilities of the Geostationary Operational Environmental Satellite (Goes) are analyzed to obtain multiyear time histories of Gulf Stream meanders. Radiative transfer calculations using monthly mean profiles of atmospheric temperature and moisture are shown to overestimate cloud‐free equivalent soundings by 2–5 K. A simple relation is derived between temperature at the satellite, sea surface temperature, and transmissivity of the atmosphere at 11.6 μm, which allows an observer to determine if a known sea surface temperature gradient is observable from Goes knowing only the precipitable water content along the slant path to the spacecraft. More than 2 years of Goes observations of Gulf Stream meanders are analyzed as a randomly spaced time series using least squares spectral analysis; the dominant periods in the spectra, based on 1976–1978 data, are 250,65, and 10 days in the Gulf of Mexico; 30 and 6 days off Onslow Bay, North Carolina; and 45 and 5 days off New England. A summary of the meanders between the Yucatan Strait and the Grand Banks shows that the largest latitudinal variability is associated with the Gulf Loop Current. Comparison of meander periods with least squares spectra of historical Florida Current transports suggests that meanders in the Gulf of Mexico are related to variability with 4‐ to 16‐day and 40‐ to 100‐day periods in the flow.