Phaleria macrocarpa or Mahkota Dewa has been a unique plant because of its antioxidant, anti-inflammatory and anti-cancer properties. The phytochemical studies of this plant have revealed the presence of bioactive compounds: phenolic compound, terpenes (isoprenoids) compounds, alkaloids compounds, and benzophenones compounds. Researches done on its have shown its ability to treat some diseases and serves as herbal medicines. The aim of this review is to summarize and evaluate the existing researches regarding the pharmacological effects, phytochemical properties, and toxicological studies of Phaleria macrocarpa. This review is expected to be useful for researchers working on the potential roles of Phaleria macrocarpa in the treatment of diseases or for product development.