Aim: There is growing evidence regarding the imaging ultrasound findings of coronavirus disease 2019 COVID-19. Multi-organ ultrasound has played a significant role in the diagnosis and follow-up of these patients. The aim of this study was to describe the ultrasound findings at pulmonary, cardiac and deep venous system of the lower extremities in patients with SARS-COV-2 infection. Material and method: Prospective, cross-sectional, observational study was conducted in patients with confirmed COVID-19 who underwent a multi-organ point-of-care ultrasound (POCUS) examination during hospitalization. Results: A total of 107 patients were enrolled. Lung involvement was present in 100% of the patients, 93.4% bilaterally involvement. The most affected lung area was the posteroinferior (94.39%) followed by the lateral (89.72%). Subpleural consolidations were present in 71% of patients and consolidations larger than 1 cm in 25%. More echographic lung involvement is relational with the degree of respiratory insufficiency. Only two patients had proximal deep vein thrombosis in the lower extremities, 27 angiography tomography scan were performed and pulmonary thromboembolism was confirmed in 14 patients. The most frequent echocardiographic findings were impaired left ventricular relaxation and left ventricular hypertrophy. All patients with thromboembolic disease had severe or critical echocardiographic pulmonary involvement. Conclusions: Multi-organ POCUS ultrasound may be useful for the manifestations of COVID-19. The degree of lung ultrasound involvement was related to the degree of respiratory failure and to the presence of VTED. The relationship between DVT and PTE was lower than expected. Cardiac involvement has little relevance in our series.

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