Intraperitoneal administration of hormones or of certain neuropharmacological agents does not affect initial blastema formation in adult newts (Notophthalmus viri-descens). Hormonal treatment accelerates the onset of the morphogenetic phase of regeneration. In contrast, treatment with chlorpromazine (alone or with growth hormone), gua-nethidine, or atropine retards or represses the onset of morphogenesis. These results suggest that some interaction between the nervous and endocrine systems is required in promoting the proliferative and the morphogenetic stages of forelimb regeneration.
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