No abstract

No abstract

ume regulation as well as in transepithelial acid/base The human AE2 gene (HGMW-approved symbol transport (Alper, 1991). AE proteins are encoded by a SLC4A2) encompasses over 17 kb and contains 23 ex-family of genes, three of which (AE1, AE2, and AE3 ons intervened by 22 introns. The size range for the genes) have been clearly identified (cf. reviews: Alper, exons is 90-255 bp, whereas that for the introns is 80 1991; Kopito, 1990; Jennings, 1992b). AE1 protein (also bp to 2.2 kb. Exon 1 consists solely of 5-untranslated termed band 3) is the most abundant protein in red sequence, and exon 2 encodes the amino-terminal end blood cell membrane (Fairbanks et al., 1971). The huof the antiport protein. Primer extension experiments man protein has been purified and characterized (Lusuggest that there are multiple transcription initiation kakovic et al., 1981), and its cDNA has also been cloned sites in leukocytes. The putative promoter region of and sequenced (Tanner et al., 1988;Lux et al., 1989). Kudrycki et al., 1990; Chow et al., 1992; of the human AE1 gene. The human AE2 gene (which Negrini et al., 1995). Gehrig et al. (1992) reported a has been previously mapped to chromosome 7) has compiled sequence of the putatively complete cDNA for three more introns than the human AE1 gene (mapped the human kidney AE2. AE2 mRNA seems to be widely to chromosome 17), but downstream of intron 7 in the AE2 gene (corresponding to intron 4 in the AE1 gene), expressed, and the encoded protein appears to be inthese two genes show a rather similar exon/intron or-volved in transepithelial bicarbonate secretion, while ganization. ᭧ 1997 Academic Press

No abstract

No abstract