Pulmonary function and quality of life in children and adolescents with bronchiolitis obliterans post-adenoviral infection Introduction: Adenovirus infection is an important cause of pneumonia in Chilean children. Postinfectious Bronchiolitis Obliterans (PIBO) is the most important complication. There are few studies assessing pulmonary function and quality of life in PIBO patients. Objective: The aim of this study is to assess the pulmonary function and the quality of life of patients with PIBO and the correlation between both variables. Methods: 14 children with PIBO in follow up at the pediatric pulmonology outpatient clinic of a public children hospital were included in this study. Study period: April 2009-April 2010. Pulmonary function was assessed in a medical visit by spirometry, fl ow/volume curve and intrathoracic gas volume measurement. The following indices were analyzed FVC, FEV 1 , FEF 25-75 , FEV 1 /FVC, RV, TLC, RV and RV/TLC. A survey of a self-administered Quality of Life (PedsQL, version 4.0, Spanish for Chile) was applied at the visit to investigate their global, physical and psychosocial quality of life. The Pearson linear correlation between quality of life and the pulmonary function test parameters was assessed, in the statistical analysis a p value < 0.05 was considered signifi cant. Results: The mean age of our patients was 12.4 (range: 9-19 years-old). The functional alterations were characteristics of an obstructive respiratory disorder in 64.3% of the patients. Average pulmonary function test indices showed decreases in

Introduction:It has been shown that asthma control and quality of life in children have moderate correlation, however FEV 1 would have only a weak correlation with these control parameters. Our objective was to measure clinical correlation and concordance between parameters of pediatric asthma control in Chilean children. Methods: Study carried out in the Unit of Respiratory Diseases, Roberto del Río Children's Hospital, between November 2009 and May 2010, in a series of persistent asthmatic children between 12 and 17 years old. We measured the correlation and agreement between asthma quality of life (PAQLQ Juniper), asthma control (ACT) and FEV 1 (percentage predicted). We used coeffi cient of Spearman rank correlation (rs) and kappa index. The sample size was calculated considering a power of 80% and p < 0.05. Results: We enrolled 88 patients, average age 13.4 years old, 61% male. Correlation PAQLQ and ACT (rs: 0.48), ACT and FEV 1 (rs: 0.11), PAQLQ and FEV 1 (rs:-0.1). Concordance PAQLQ < 6 points and ACT < 20 points (kappa: 0.46). Concordance ACT < 20 points with FEV 1 < 80% (kappa: -0.02), concordance PAQLQ < 6 points with FEV 1 < 80% (kappa: -0.02).Conclusions: The quality of life and asthma control have moderate correlation. FEV 1 weakly correlation with ACT and negative correlation with PAQLQ. The best cut-off point to identify uncontrolled asthma was obtained with ACT < 20 points and PAQLQ Juniper < 6 points. FEV 1 <80% do not have good agreement with ACT and PAQLQ to detect uncontrolled asthma. ResumenIntroducción: Se ha demostrado que el control del asma y la calidad de vida en niños se correlacionan en forma moderada, sin embargo, el VEF 1 sólo tendría una correlación débil con dichos indicadores de control. El objetivo de este estudio fue medir la correlación clínica y concordancia entre indicadores de control del asma pediátrica en niños chilenos. Pacientes y Métodos: Estudio realizado en el policlínico de enfermedades respiratorias del Hospital Roberto del Río, entre noviembre de 2009 y mayo de 2010, con un grupo de asmáticos persistentes de 12 a 17 años. Se midió la correlación y concordancia entre calidad de vida (PAQLQ de Juniper), control del asma (ACT) y VEF 1 (porcentaje del predicho). Se utilizó el coefi ciente de correlación por rangos de Spearman (rs) e índice de kappa. El tamaño muestral se calculó considerando un poder de 80% y p < 0,05. Resultados: Se enrolaron 88 pacientes, promedio de edad 13,4 años, 61% de género masculino. Correlación PAQLQ y ACT (rs: 0,48), ACT y VEF 1 (rs: 0,11), PAQLQ y VEF 1 (rs:-0,1). Concordancia PAQLQ < 6 puntos y ACT< 20 puntos (kappa: 0,46). Concordancia ACT < 20 puntos con VEF 1 <80% (kappa: -0,02), concordancia PAQLQ < 6 puntos con VEF 1 < 80% (kappa: -0,02). Conclusiones: La calidad de vida y el control del asma tienen correlación moderada. El VEF 1 presenta correlación débil con ACT y negativa con PAQLQ. El mejor punto de corte para detectar asma no controlada se obtuvo con ACT < 20 puntos y PAQLQ de Juniper < 6 puntos. EL VEF 1 < 80% no tiene buena c...

Asthma and psychiatric disorders in childhood and adolescense Comorbid psychiatric disorders are common in asthma and can be divided into externalizing or internalizing disturbances. These conditions increase the morbidity of asthma in young people. Caregivers of asthmatic children are also susceptible to these diseases, which have been linked to the genesis and symptoms of asthma in children. Treatment of mental health disorders in children and caregivers should consider drugs, psychoeducation, family therapy and cognitive behavioral.

Comparison of asthma control questionnaire in children (CAN) and GINA control recommendations Introduction: Several questionnaires of asthma control exist for children, but few of them have been validated in Spanish being applicable to our country. Patients and Methods: We compared the asthma control questionnaire in children (CAN) in two versions in Spanish with the control questionnaire recommended by GINA. The study was carried out at Roberto del Río Children's Hospital, Santiago de Chile. We measured concordance and diagnostic tests. The sample size was calculated considering a power of 80% and a p value < 0,05. Results: We enrolled to 214 asthmatic children from 5 to 14 yearsold. Male gender 60.3%. Mean of age was 8.3 years. Controlled asthma in children 5 to 8 years-old was 12.1% for GINA and 35.6% for CAN guardian version. CAN guardian achieved 76.5% to agree in uncontrolled asthma (Kappa 0.39). Sensitivity, specificity, positive predictive and negative predictive values for children from 5 to 8 years-old were 100%, 73%, 34% and 100% respectively. Controlled asthma in children from 9 to 14 years-old reached 23.2% with GINA and 43.9% with CAN. The 79.2% of the controlled asthmatic by GINA were correctly diagnosed by CAN (Kappa 0.55). Sensitivity, specificity, positive predictive and negative predictive values in 9 to 14 years-old children were 100%, 73%, 53% and 100% respectively. Conclusion: CAN is an instrument of easy implementation in our practice that achieves acceptable agreement with GINA recommendations, whose main utility is in identifying the patients with uncontrolled asthma.

Impact of the overweight and obesity in the pediatric asthma (27.5%, 46.3%, 44.4%, p = 0.03