The effect of two supplements containing resveratrol (“Resveratrol” and “Enoant”) on the psycho-emotional state of animals with an initial index of anxiety and depression above 0.5 was studied. For this, the “Elevated plus maze” (EPM) and “Forced swim test” (FST) were used. “Resveratrol” significantly reduces the index of depressivity (ID) in males on the 7th and 14th days of application, in females – only on the 14th day. No significant influence on the anxiety index (AI) was found in both sexes. “Enoant” significantly reduces the ID in males on the 7th day, but not on the 14th day, while no significant differences were observed in females. However, unlike “Resveratrol”, “Enoant” significantly reduces the AI on the 14th day in rats of both sexes.