27The process involved in the research, discovery and development of drugs is 28 characterized by high extensive and complex cost linked to scientific and 29 technological innovations, and it is necessary to study and verify the progress of 30 research carried out in the field that results in patent applications. Aniba riparia 31 (Nees) Mez is a plant species often used for therapeutic purposes, where its 32 pharmacological properties are associated to the presence of alkaloids called 33 riparins. 5 synthetic analog compounds (riparins A, B, C, D, E and F) were 34 developed from natural riparins. These molecules, natural and synthetic, showed 35 several pharmacological activities in tests performed in vitro and in vivo, 36 highlighting the Central Nervous System (CNS). The objective of this work was 37 to evaluate the physical-chemical, pharmacokinetic parameters (absorption, 38 distribution, metabolism, excretion and toxicity) and pharmacodynamic 39 parameters (bioactivity and adverse reactions) of Riparin B by means of in silico 40 computational prediction. Online software such as Pre-ADMET, SwissADME, 41 Molinspiration and PASS on line were used for the analysis. Riparin B fits the 42 characteristics of druglikeness, pharmacokinetic properties appropriate to the 43 predicted patterns and activities within the scope for the treatment of AD, 44 demonstrating a possible potential in the inhibition of AChE. Therefore, in silico 45 results allow us to conclude that riparin B is predicted to be a potential future drug 46 candidate, especially via oral administration, due to its relevant Drug-likeness 47 profile, bioavailability, excellent liposolubility and adequate pharmacokinetics,48including at the level of CNS, penetrating the blood-brain barrier. 49 50 73the natural molecules of this species, there are synthetic analogues known as 74 riparins A, B, C, D and F, which share structures similar to natural molecules [5] . 75 4 Synthetic riparin analogues have already demonstrated antioxidant, 76including analysis of isolated mitochondria of the brain of mice [6,7] , antimicrobial [8] , 77 antiparasitic [9] , as well as leishmanicide [10] , vasodilator [7] and anti-inflammatory [11] 78 activities. Among the properties of synthetic riparins, their action in the Central 79Nervous System (CNS), such anxiolytic effects [12] in anxiety models, without 80 affecting the locomotion of the animals used in the experiment [7] , which make 81 them target molecules of new studies aimed at obtaining therapeutic alternatives, 82 and can be used in the treatment of AD. 83However, there is a significant problem that still remains in the drug 84 discovery procedure, particularly in the later stages of conducting research: the 85 analysis of the properties of ADME (absorption, distribution, metabolism and 86 excretion) and the evident toxicity of drug candidates. Over 50% of drug 87 candidates fail due to poor analysis of ADME/Tox during a drug design [2] . 88 To evaluate the physicochemical, pharmacokinetic (absorption,...