The purpose of this research was to determine the effectiveness of Ketumpang Air (Peperomia pellucida) to reduce the impact of edema caused by Smilax sp. This research was conducted in the integrated laboratory of the Muhammadiyah Education University (UNIMUDA) Sorong. The variables of this research were Ketumpang Air as the independent variable and the impact of Smilax sp. as the dependent variable. The results showed that the giving of Ketumpang air had a significant effect in reducing edema caused by the use of Smilax sp. with a significance level of 5% is 0.00089