Measles Rubella (MR) immunization is a way to actively increase a person's immunity against antigens (measles and rubella viruses), so that if later exposed to similar antigens, measles and rubella infection will not occur. The purpose of this study was to determine the association of information and socio-cultural sources with the administration of Measles Rubella (MR) immunization in children aged 9 months to 5 years in the working area of Lubuk Buaya Health Center, Padang City. This study was a quantitative study with cross sectional design conducted at Lubuk Buaya Primary Health Center from September 2019 to October 2019. There were 97 mothers with 9 month until 5 years childrens became sample of this study. The mother as the respondent was interviewed directly with a questionnaire. Data will analyzed in univariate and bivariate by using chi-square analysis (p<0,1). The results showed the percentage of mothers who gave Measles Rubella (MR) in the Work Area of the Lubuk Buaya Public Health Center in Padang City was 59.8% while the percentage of mothers who did not give MR immunization was 40,%. The majority of respondents found good sources of information (29%) and good and poor socio-cultural information (43%). There is a relationship between the source of information (p = 0.027) and social culture (p = 0.001), with the administration of Measles Rubella (MR) immunization in the Work Area of the Lubuk Buaya Health Center in Padang City. From the results of the study it can be concluded that the better the source of information obtained by the mother, the higher the level of maternal participation in the administration of Measles Rubella immunization to children. The inclusion of MR immunization also depends on the mother's negative and positive socio-cultural exposure as well as on the mother's perception in the socio-cultural understanding itself. There is a significant association between the source of information with the administration of Measles Rubella (MR) immunization. It is expected that mothers should administer Measles Rubella (MR) immunization by taking into account information and socio-cultural sources so as to prevent measles and rubella.