The technologies employed for the preparation of conventional tissue engineering scaffolds restrict the materials choice and the extent to which the architecture can be designed. Here we show the versatility of stereolithography with respect to materials and freedom of design. Porous scaffolds are designed with computer software and built with either a poly(D,L-lactide)-based resin or a poly(D,L-lactide-co-epsilon-caprolactone)-based resin. Characterisation of the scaffolds by micro-computed tomography shows excellent reproduction of the designs. The mechanical properties are evaluated in compression, and show good agreement with finite element predictions. The mechanical properties of scaffolds can be controlled by the combination of material and scaffold pore architecture. The presented technology and materials enable an accurate preparation of tissue engineering scaffolds with a large freedom of design, and properties ranging from rigid and strong to highly flexible and elastic.
The three isomeric dichlororuthenium(II) complexes α-, β-, and γ-[Ru(azpy)2Cl2] (azpy = 2-phenylazopyridine) have been investigated for their cytotoxic properties against a series of tumor-cell lines. The complex α-[Ru(azpy)2Cl2] appears to have a very high cytotoxicity (on the order of magnitude as that of the well-known antitumor complexes cisplatin), which stands in contrast to the much lower cytotoxicity of the trans-dichloro complex γ-[Ru(azpy)2Cl2] and the cis-dichloro isomer β-[Ru(azpy)2Cl2].
An easy and cheap fabrication method for intricate polydimethylsiloxane microfluidic devices is presented. The acrylonitrile butadiene styrene scaffold‐removal method uses cheap, off‐the‐shelf materials and equipment for the fabrication of intricate microfluidic devices. The versatility of the method is proven by the fabrication of 3D multilayer, ship‐in‐a‐bottle, selective heating, sensing, and NMR microfluidic devices. The methodology is coined ESCARGOT: Embedded SCAffold RemovinG Open Technology.
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