Both researchers and Government Agencies see aviation as an important driver for regional development and national integration. Thus, this sector has been a matter of concern for the government who has ways to stimulate the aero activity. The Regional Aviation Development Program (PDAR) has been currently under development implemented in Brazil. This program foresees public investments in airport infrastructure and operational subsidies for airlines to enhance the sector operation and increase the number of locations served by regional aviation. This paper presents a model for estimating passenger demand potential through multiple linear regression to cover the great majority of the federative units (states) of Pernambuco, Paraíba, Rio Grande do Norte, Ceará, and Piauí in the northeast of Brazil. Subsequently, localities are suggested to optimize the resources of the PDAR, and we concluded that it is likely that there are regions with higher demand potential than some regions, which are already served by the airlines. Hence, we assumed that by strategically directing investments to specific localities, companies operate without subsidies, which in turn can be directed to airlines used to integrate the country. This making regional aviation more sustainable leading development to isolated localities, and thus efficiently contributing to reducing the Brazilian social inequality.