The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

RESUMOEste estudo busca avaliar a qualidade de vida dos professores do ensino fundamental de uma escola da rede pública brasileira. Tratase de um estudo transversal realizado com 26 professores. Utilizouse um questionário sociodemográfico, o SF-36, Questionário Nórdico e o Inventário de Depressão de Beck. Observou-se a prevalência do sexo feminino (69,6%) e com cônjuge (60,9%). A maioria possuía apenas graduação (56,5%). Considerando a dor musculoesquelética, foi encontrada maior ocorrência nos membros inferiores (34,8%) e na coluna (47,8%), sendo que apenas 34,8% dos docentes entrevistados relataram algum tipo de afastamento por queixa de dor em algum dos segmentos. Apenas 5,35% dos professores apresentaram algum indicativo de depressão. Quanto à qualidade de vida, constatou-se um escore mínimo de 56,04 para "Estado geral de saúde" e o máximo de 84,38 para o domínio "Capacidade funcional", sendo o domínio "Limitações por aspectos físicos" o mais afetado quando comparado dor com diminuição da qualidade de vida. Houve uma depreciação da qualidade de vida dos docentes que relataram dores, principalmente nas costas, nos últimos 12 meses. Constata-se haver comprometimento de todos os domínios do SF-36, portanto infere-se que a sintomatologia dolorosa e depressiva contribui para uma redução da qualidade de vida do docente.(Gomes A, Amorim T, Ferreira A, 2017. ABSTRACTThis study aims to evalue the quality of life of teachers of a Brazilian public basic school. This is a cross-sectional study done with 26 teachers. It was used a social-demographic questionnaire, the SF36, the Nordic Questionnaire and the Inventory of Beck Depression. It was observed that most teachers are female (69,6%) and married (60,9%). Most of them have only graduation (56,5%). Considering the musculoskeletal pain, it was found higher occurrence in lower members (34,8%) and in column (47,8%), and only 34,8% of them related some kind of sick leave because of pain in some of the segments. The study showed that 5,35% of the teachers have an indicative of depression. About quality of life, it was detected a minimum score of 56,04 for "general state of health" and the maximum of 84,38 for the domain "functional capacity", with the domain "limitations for physical aspects" being the most affected when compared pain with loss of quality of life. It was observed a quality of life depreciation on the teachers that reported pain, most of them in their backs, through the last 12 months. All the domains of SF-36 were engaged, then we can infer that the painful and depressive symptomatology contributes to a reduction of teachers' quality of life.

Caracterização da Consulta de Enfermagem na Atenção à Pessoa com Hipertensão e Diabetes Characterization of the Nursing Consultation in the Care of the Person With Hypertension and Diabetes