Epilepsy is a common neurological disease characterized by spontaneous recurrent seizures. Resection of the epileptogenic tissue may be needed in approximately 25% of all cases due to ineffective treatment with anti-epileptic drugs. The surgical intervention depends on the correct detection of epileptogenic zones. The detection relies on invasive diagnostic techniques such as Stereotactic Electroencephalography (SEEG), which uses multi-modal fusion to aid localizing electrodes, using pre-surgical magnetic resonance and intra-surgical computer tomography as the input images. Moreover, it is essential to know how to measure the performance of fusion methods in the presence of external objects, such as electrodes. In this paper, a literature review is presented, applying the methodology proposed by Kitchenham to determine the main techniques of multi-modal brain image fusion, the most relevant performance metrics, and the main fusion tools. The search was conducted using the databases and search engines of Scopus, IEEE, PubMed, Springer, and Google Scholar, resulting in 15 primary source articles. The literature review found that rigid registration was the most used technique when electrode localization in SEEG is required, which was the proposed method in nine of the found articles. However, there is a lack of standard validation metrics, which makes the performance measurement difficult when external objects are presented, caused primarily by the absence of a gold-standard dataset for comparison.

The aim of this study was to evaluate the clinical utility of Cone Beam Computed Tomography (CBCT) in cases of medium and high endodontic complexity. The relevance of CBCT to define treatment was evaluated through the Wittenberg questionnaire and the variation in treatment plans after CBCT exam analysis. The sample (n=40) was chosen for convenience over a period of 4 months. It considered the current recommendations to request CBCT exams before performing root canal treatments. Data collection was carried out through a survey applied to the treating clinicians, after examining the information obtained by the CBCT system. Data were analyzed with the Stata version 13 software, and the Chi-square test was used for inferential analysis. A 95% confidence interval was considered. The most frequent dental groups corresponded to upper posterior and upper anterior teeth (47.5% and 30.0%); the cases were equally distributed according to complexity (50% and 50%). The main reason for requesting CBCT exams corresponded to complex anatomy and/or atypical canal system (37.5%). The use of CBCT increased confidence in the initial treatment chosen by clinicians in 50% of cases according to the Wittenberg questionnaire, and a 45% variation in treatment plans was observed. There was no statistical relationship between complexity and the variables studied. CBCT contributed greatly to the therapeutic management of cases regardless of their complexity.