The COVID-19 pandemic is currently a worldwide threat and concern, not only because of COVID-19 itself but its sequelae. The aim of this study was to evaluate whether a relation between COVID-19, Long COVID, and the prevalence of mental health disorders exist. A total of 203 people from Tabasco were included in this study, answering a survey integrated by three dominions: General and epidemiological data, the DASS-21 test (to determine the presence of signs or symptoms suggestive of depression, anxiety, and/or stress) and an exploratory questionnaire about Long COVID syndrome. A descriptive and inferential statistical analysis was made via Microsoft Excel and Graphpad Prism software, evaluating differences through the Mann–Whitney U test and considering p < 0.05 as statistically significant. Of the 203 people surveyed, 96 (47.29%) had had COVID-19 and 107 (52.71%) had not; from the ones that had COVID-19, 29 (30.21%) presented mental health disorders and 88 (91.66%) presented at least one symptom or sign of Long COVID syndrome; meanwhile, 31 (32.29%) presented 10 or more symptoms or signs. From the comparison between the population with previous mental health disorders and COVID-19 and those without background disorders or COVID-19, the results were the following: 27.58% vs. 16.82% presented severe depression, 48.27% vs. 17.75% presented severe anxiety, and 27.58% vs. 20.56% presented severe stress. A high prevalence of mental health effects was observed in patients without COVID-19 and increased in the population with Long COVID syndrome and previous mental health disorders.

Objective: To describe the geographical distribution of dengue fever cases in fl ooded areas of Villahermosa, Tabasco, in 2010. Methods: Cross-sectional, descriptive study. Universe: Colonies with antecedents of fl ooding during the inundation of the State, located in Villahermosa, Tabasco: Gaviotas Norte, Gaviotas Sur, La Manga 1 th Section, La Manga 2 nd Section and La Manga 3 th Section. Convenience sample without randomization. Variables: location, dengue fever case. Analysis: descriptive statistic. Software: SPSS version 11.0. Results: 540 individuals were included. The distribution was: Gaviotas Norte, 36.1%; Gaviotas Sur, 24.8%; La Manga 1 th Section, 13.8%; La Manga 2 nd Section, 13.2%; and La Manga 3 th Section, 12.1%. We found three cases with positive serology of IgG (0.6%) and fi ve cases of positive IgM (0.9%). The geographical distribution was associated with the proximity to two water bodies: Rio Grijalva and Laguna El Encanto. Conclusions: It is necessary to reinforce preventive interventions in the proximity of bodies of fresh water.

Introducción: El ambiente educacional es un aspecto vital para obtener resultados de calidad en las escuelas de medicina, por ello es importante contar con instrumentos confiables que evalúen la percepción de los estudiantes. De los instrumentos que existen, la escala Dundee Ready Education Environment Measure (DREEM) es la más utilizada a nivel internacional para ese fin. Objetivo: Validar la escala DREEM después de traducirla y adecuarla del idioma inglés al español-mexicano. Método: Para validar la traducción se utilizó metodología cualitativa que consideró traducción, retrotraducción y tres grupos focales. Para validar la consistencia interna se utilizó el cálculo del coeficiente alfa de Cronbach y correlación corregida ítem-subescala, en lo expresado por una muestra de 110 estudiantes de medicina. Resultados: Sobre la traducción literal y primera adecuación hubo total coincidencia positiva de los traductores revisores en 40 de los 50 ítems. Diez ítems donde no hubo coincidencia, se volvieron a redactar de acuerdo con la reconciliación de las sugerencias de los traductores. A través de los grupos focales se identificaron ocho ítems que se adecuaron para que fueran comprendidos por los estudiantes, tratando de no modificar el campo semántico. El coeficiente de alfa de Cronbach calculado para la validación de la consistencia de las subescalas, resultó en la percepción de la enseñanza y los docentes >0.8, la autopercepción académica y la atmósfera >0.7 y la autopercepción social <0.6 considerándose la fiabilidad buena, aceptable y pobre, respectivamente. El alfa de Cronbach del DREEM global se calculó en 0.93 y se considera excelente. Conclusiones: La escala DREEM no perdió su fiabilidad con la traducción realizada, las sustituciones de términos y adecuaciones del original diseñado en idioma inglés, por lo tanto, se pueden aplicar en México a estudiantes de la Licenciatura en Medicina para indagar la percepción que tienen sobre el ambiente educacional.

Introduction: Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection is characterised by a viral phase and a severe pro-inflammatory phase. The inhibition of the JAK/STAT pathway limits the pro-inflammatory state in moderate to severe COVID-19. Methodology: We analysed the data obtained by an observational cohort of patients with SARS-CoV-2 pneumonia treated with ruxolitinib in 22 hospitals of Mexico. The applied dose was determined based on physician’s criteria. The benefit of ruxolitinib was evaluated using the 8-points ordinal scale developed by the NIH in the ACTT1 trial. Duration of hospital stay, changes in pro-inflammatory laboratory values, mortality, and toxicity were also measured. Results: A total of 287 patients were reported at 22 sites in Mexico from March to June 2020; 80.8% received ruxolitinib 5 mg BID and 19.16% received ruxolitinib 10 mg BID plus standard of care. At beginning of treatment, 223 patients were on oxygen support and 59 on invasive ventilation. The percentage of patients on invasive ventilation was 53% in the 10 mg and 13% in the 5 mg cohort. A statistically significant improvement measured as a reduction by 2 points on the 8-point ordinal scale was described (baseline 5.39 ± 0.93, final 3.67± 2.98, p = 0.0001). There were 74 deaths. Serious adverse events were presented in 6.9% of the patients. Conclusions: Ruxolitinib appears to be safe in COVID-19 patients, with clinical benefits observed in terms of decrease in the 8-point ordinal scale and pro-inflammatory state. Further studies must be done to ensure efficacy against mortality.

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