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Currently a significant place in the list of already existing and developing medicines that are associated with high hopes, take drugs created through genetic engineering and modern biotechnology. The foundations of these drugs are genetically engineered drugs on the basis of the substance of cytokines. A new trend in the system of medical correction of the course of wound process in recent years is the use of tumor necrosis factor. Development of dosage forms for external use, combining the structure of the active substances and excipients, acting on the wound healing process is the actual problem, in which one of the main places is local treatment with ointments, gels and liniments. The research presented in this article allows to confirming the hypothesis that “the tumor necrosis factor-alpha (TNF-alpha or TNF-alpha) is a key mediator in the process of wound healing, especially in protracted and chronic variants course of inflammation". The authors note that one of the directions in the creation of new forms of drugs TNF-alpha is the use of different polymers. Modified-polymers TNF-alpha are being actively studied, for example, in Japan and China. Currently, in many countries the development and extensive research on new forms of TNF-alpha are aimed at creation of effective new generation medications.