This review focuses on the salting-out effect and its use in chromatographic analysis, mainly thin-layer chromatography. First, a theoretical background is given, focusing on the general salting-out theory and a comparison with chaotropic salt addition, practised recently in reversed-phase chromatography. All the salting-out chromatographic applications in literature (from the 1960s to the present moment) are then reviewed.

& Thirty-five simple model compounds were chromatographed on silica plates with twelve inorganic salts dissolved in high concentrations (0.5-4 mol=L) in water. The resulted retention dataset was analyzed chemometrically by Principal Component Analysis to find interesting dependences and trends in the retention. It can be concluded, that first PC (explaining majority of variance) is connected with compound contribution, independent of the salt used. The differences between the salting-out effect intensities are modeled by second PC. The third PC mainly explains differences in retention between salts, whereas the fourth one represents differences between salting-out intensities among salts.

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