Introduction: Obesity is a chronic metabolic disease, characterized by an increased accumulation of fat in adipose tissue, to the extent that damages health and leads to the development of numerous complications. The increasing distribution of obesity has caused a large increase in the incidence of metabolic syndrome. Metabolic syndrome comprises a set of related risk factors for cardiovascular diseases and type 2 diabetes. The basis of therapeutic modalities of obesity make diet, exercise and lifestyle changes. Aim: To assess the effect of reduction of body weight, performed by therapeutic lifestyle intervention, in the sample of extremely obese men without diabetes, on components of the metabolic syndrome and metabolic syndrome itself. Material and methods: Prospective study included 38 extremely obese men (mean age 41.68 ± 11.93 years, mean weight 142.08 ± 20.11kg, mean BMI 45.90 ± 5.65kg / m 2 ). Anthropometric parameters and blood samples for biochemical analysis were measured before and after the reduction of body weight using therapeutic program, which included a very low calorie diet (VLCD) and low calorie diet (LCD) with physical activity. The relationship between variables was tested by Student's t-test and Wilcoxon's rank-sum test. Results: Highly statistically significant reduction was found in waist circumference, systolic and diastolic blood pressure and triglyceride levels (p < 0.001), while increased HDL and reduced fasting glucose levels were statistically significant (p < 0.05). Before the diet, 63% of the extremely obese subjects had a diagnosis of the metabolic syndrome, while after the reduction of the body weight by conventional manner, the percentage of subjects with metabolic syndrome was 18% (p < 0.001). Conclusion: Weight loss after comprehensive lifestyle management in extremely obese men without diabetes improves all parameters of the metabolic syndrome and metabolic syndrome itself.

The aim: The aim of the study was to determine if there is any influence of prenatal detection on postnatal correction of the fetal pyeloureteral segment stenosis. Materials and Methods: The study included 77 patients who were prenatally diagnosed with one of the urinary tract anomalies. Results: The Apgar (Ap) score mean value in seven patients where the anomaly was detected before the 30 th week of pregnancy was 9.14 ± 0.37, while the Ap score mean value for eight patients after the 30 th week of pregnancy was 7.87 ± 0.64. By testing these values, the authors have established that there was a significantly high difference for t = 4.572 and p = 0.001. Discussion: It is necessary for research to be carried with the objective to find the most simple and efficient methods of diagnosing and treating the obstruction of the pyeloureteral segment.