Aim of the study: To investigate the relationship of renal function markers and lipid metabolism parameters in obese adolescents. Material and methods: The study comprised 76 children aged 11-17 years, hospitalised due to: obesity (group I -19 children) or obesity accompanied by obesity-induced hypertension (group II -30 children) or normosthenic children with a diagnosed tension headaches (control group -27 children). A subgroup with metabolic syndrome (MS -16 children) was also separated. Renal function was assessed on the basis of: serum creatinine concentration, glomerular filtration rate estimated using Schwartz eqation (eGFR), determination of plasma and urinary neutrophil gelatinase-associated lipocalin and cystatin C. On the basis of statistical analysis, it was checked whether renal function markers depend on lipid metabolism parameters. Results: In the study groups mean creatinine concentrations were significantly higher and eGFR values significantly lower than in the control group, but they remained within norm. Differences in plasma and urinary neutrophil gelatinase-associated lipocalin concentrations were not significant. Mean cystatin C concentrations were significantly higher in the group of obese children. Multiple linear regression analysis showed that the most important predictor was: LDL-C for urinary neutrophil gelatinase-associated lipocalin (R2 = 0.42) and TG for eGFR (R2 = 0.44) concentrations in group I; cholesterol for creatinine concentrations in MS group (R2 = 0.44). Conclusions: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.

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WstępW pracy przedstawiono wyniki badania ankietowego prowadzonego od maja do listopada 2020 r. wśród nastolatków zamieszkujących województwo śląskie. Celem badania była ocena stosunku młodzieży do problemu otyłości oraz aktywności fizycznej.Materiał i metodyAnkietę – w wersjach elektronicznej oraz papierowej – przeprowadzono w losowo wybranych szkołach oraz wśród pacjentów wybranych placówek medycznych. W badaniu uczestniczyło 527 respondentów, w tym 261 w wieku 11–14 lat (49,5%) i 266 w wieku 15–18 lat (50,5%).Wyniki31,8% dzieci w wieku 11–14 lat oraz 15,4% w wieku 15–18 lat relacjonowało należną aktywność fizyczną. 20% respondentów przyznawało się do pozostawania obojętnymi wobec dokuczania innym z powodu nadmiernej masy ciała. 53% nastolatków w wieku 11–18 lat nie potrafiło podać definicji otyłości, a 36,6% nie potrafiło wymienić powikłań otyłości. 14% respondentów miało negatywne skojarzenia związane z osobami otyłymi. 26,2% wykazało brak zainteresowania problemem otyłości.WnioskiIstnieje pilna potrzeba upowszechniania wśród nastolatków: wiedzy na temat uwarunkowań i następstw otyłości, postawy szacunku względem wszystkich osób – niezależnie od ich masy ciała, aktywności fizycznej jako podstawowej metody walki z otyłością.

Introduction: Obesity and hypertension are associated with organ complications, including kidney diseases. It is necessary to search for the methods of early detection of these complications. Aim: The aim of the study was to assess renal function in obese adolescents, based on lipocalin-2 and cystatin C levels in relation to creatinine, estimated glomerular filtration rate and leptin levels. Materials and methods: The study included 76 children aged 11–17 years, with obesity or with obesity and obesity- induced hypertension or normosthenic children with tension headaches (control group). Renal function was assessed based on serum creatinine and estimated glomerular filtration rate (Schwartz equation). Plasma and urine lipocalin-2, serum cystatin C and leptin levels were determined by ELISA. Results: Renal function assessed by creatinine level and estimated glomerular filtration rate was normal in all patients, but mean creatinine levels were significantly higher and estimated glomerular filtration rate was significantly lower in the study groups compared to controls. No significant differences were found in plasma and urine lipocalin-2 levels. Mean cystatin C level was significantly higher in the obese group. We have found a weak positive correlation between plasma lipocalin-2 and creatinine levels and its weak negative correlation with estimated glomerular filtration rate, as well as a positive correlation for leptin and cystatin C levels in the obese group. Conclusion: The role of plasma and urine lipocalin-2 and serum cystatin C in the assessment of renal function in obese adolescents with or without obesity-induced hypertension is ambiguous. The relationship between cystatin C and leptin levels in obese children also requires further research.