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Acromegaly is a multisystem chronic disease characterized by hypersecretion of growth hormone. Effective treatment of acromegaly is extremely necessary, as this pathology is often associated with comorbid conditions (diabetes mellitus, arterial hypertension, sleep apnea syndrome, cardiac hypertrophy) and rare complete clinical and laboratory remission. This article describes treatment options for persistent and recurrent acromegaly that include surgery, pharmacological therapy and radiation therapy.