Introduction: Metabolic abnormalities of type-2 diabetes mellitus cause vascular dysfunction which is manifested with common cardiovascular complications such as atherosclerosis, myocardial infarction (MI), stroke, and coronary heart diseases. In spite of all these complications, there is no literature revealing the cardiac status of type-2 diabetic patients, in general and on different anti-diabetic drugs in particular, using cardiac troponin-I as a biomarker in study area and Ethiopia too. Objective of the Study: This study was, therefore, aimed to assess cardiac troponin-I in type-2 diabetic patients on anti-diabetic drugs treatment at Jimma Medical Center, Jimma, Southwest Ethiopia. Methods: To achieve the objectives of the study, a facility based cross-sectional study was conducted among type-2 diabetic patients on follow-up at Jimma Medical Center from August 1 to September 30, 2020. Systematic sampling technique was used to select 82 study participants. A 5mL of venous blood was drawn from each participant after overnight fasting using an aseptic technique and centrifuged at 3000 rpm for 10 minutes. Multiple logistic regression analysis and one way ANOVA were used for statistical data analysis. P-value <0.05 was considered as statistically significant. Results: The prevalence of elevated cardiac troponin-I was 25.6% in the study population. The mean value of serum cardiac troponin-I was lower in patients who were on metformin monotherapy as compared to patients on insulin monotherapy (11.654 ± 1.6795 versus 20.573 ± 1.8402, P<0.01). It was also lower when compared with those patients on metformin + glibenclamide combination therapy (11.654 ± 1.6795 versus 21.094 ± 2.4062, P<0.01). Conclusion and Recommendations: About 1/4 th of the study participants had elevated serum cardiac troponin-I level. Metformin monotherapy significantly reduced serum cTnI levels as compared to insulin monotherapy and metformin + glibenclamide combination therapy. Regular screening for cardiac injury using cardiac troponin-I is recommended for type-2 diabetic patients.