The tomato (Lycopersicon esculentum Mill) is an important vegetable crop in Ethiopia and is produced and eaten in large quantities throughout the nation. However, the tomato production is quite low (10 tons·ha−1) compared to the global average yield of 34 tons·ha−1 due to the repetitive use of chemical fertilizers alone, growing intensive crops that are absorbing significant amounts of the soil nutrients, and the lack of application of organic fertilizers. Therefore, it is crucial to take accurate measurements when using fertilizers in order to solve issues and boost crop yield. The study’s objective was to find out how NPSB and vermicompost fertilizers together influenced tomato growth, yield characteristics, and yield at the Wallaga University Research Site for two consecutive years (2021 and 2022). The experiment used a factorial randomized block design with two components: four levels of NPSB and four levels of vermicompost. The tomato fruit production and all of its components were strongly impacted by the primary and interaction effects of NPSB and vermicompost treatment rates. The highest fruit length was 6.26 cm, the largest fruit diameter was 5.94 cm, the shoot fresh weight was 48.25 g·plant−1, the shoot dry weight was 4.50 g·plant−1, the marketable fresh fruit per plant was 5.54 kg, and the fruit yield was 24.36 ton·ha−1 after the application of 125 kg·ha−1 NPSB plus 8 ton·ha−1 vermicompost. Application of 125 kg·ha−1 of NPSB fertilizer along with 8 tons·ha−1 of vermicompost increases net benefits by 115922.5 ETB·ha−1 as compared to a control. Therefore, in order to enhance tomato yield, it may be suggested that farmers utilize the combination of 125 kg·ha−1 of NPSB and 8 tons·ha−1 of vermicompost rather than applying any inorganic fertilizers alone.