Objective To describe transpelvic urethrostomy (TPU) as a surgical technique for the successful treatment of vestibulovaginal and urethral stenosis in a 7 month old female spayed mixed‐breed dog. Study design Case report. Sample population Female spayed mixed‐breed dog with obstructive vaginal tissue present on vaginal examination. Methods The dog presented with a history of persistent urine dribbling, stranguria, and dysuria since birth. Vaginoscopy and fluoroscopy revealed severe vestibulovaginal and urethral stenosis. An episiotomy and partial vaginectomy were performed to remove stenotic tissue. A perineal urethrostomy was attempted from a blind‐ended pouch associated with the stenotic urethral tissue but was unsuccessful. The dog was repositioned in dorsal recumbency and a postpubic urethrostomy was performed. Results Six days postoperatively, incisional dehiscence occurred at the cranial aspect of the urethrostomy. The site was revised at this location using a TPU to decrease tension at the urethrostomy site. The dog recovered uneventfully with no further complications identified after surgery. Forty‐two months after surgical intervention, the dog continued to show no clinical signs. Conclusion Transpelvic urethrostomy may be a viable surgical alternative for dogs diagnosed with urethral stenosis.