Our goal in this case report is to increase the awareness of surgeons and clinicians to rule out the possibility of mammary origin in circumstance of gastric cancer occurring in female, even in patients without a previous or concurrent history of breast carcinoma. Although not a particularly common event, it is, nevertheless, reported in the literature. The differentiation between primary gastric carcinoma and metastatic breast carcinoma is essential for planning the correct therapeutic approach, in order to avoid the patient unnecessary surgery.
Curcumin, an active substance contained in an Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account and studied as an antitumoral molecule, by relying on its interference on several biological mechanisms, such as the inhibition of inflammatory mediators, the enhancement of detoxifying enzymes’ action and processes of cell growth and proliferation. Studies show how the high dosage of curcumin in vitro inhibits colorectal tumor cells, pancreatic tumor cells, lung cancer cells and glioblastoma’s cells, interfering in signaling pathways as Wnt/β-catenin, NF-kB and PI3K/Akt and leading to cell cycle arrest and apoptosis. Furthermore, the association between curcumin and chemotherapeutic agents such as 5-fluorouracil strengthens the drug’s cytotoxicity and cells’ susceptibility towards the chemotherapeutic agent.
Il presente contributo esplora le dinamiche che sottendono la perinatalitŕ in un gruppo di donne migranti provenienti da diverse aree geografi che, con l'obiettivo di individuarne le risorse personali e contestuali, nonché gli elementi predittori di rischio. Lo studio ha in particolare esaminato le modalitŕ di parenting con cui le madri migranti vivono la propria esperienza perinatale in relazione alla identitŕ: materna, a quella del proprio figlio ed altresě culturale. I risultati della ricerca hanno configurato la gravidanza come un evento culturalmente determinato dai significati che ciascuna donna attribuisce alla gravidanza ed evidenziato come la lontananza dal proprio paese d'origine possa incrementarne la vulnerabilitŕ durante questo momento del ciclo di vita. Un elemento particolarmente riscontrato nelle interviste č il senso di solitudine per l'assenza di un sostegno da parte delle rete familiare di riferimento, che enfatizza l'esigenza di favorire da parte dei servizi sanitari un accompagnamento adeguato in situazioni di vulnerabilitŕ psicosociale.
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