Clostridium difficile infection (CDI) in non-hospitalized patients has been reported with increased frequency, whereas an association between CDI and pregnancy has not been highlighted. We report a case of toxic megacolon complicating a severe CDI during the second trimester of pregnancy in a patient without traditional risk factors, such as antibiotic use, immunodeficiency, and prolonged and recent hospitalization.

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We describe an alternative and more sustainable method for the synthesis of 2,2’‐disubstituted 3,3’‐biindoles starting from 2,2’‐diaminotolanes and (hetero)arylaldehydes. The key feature of the approach is the use of an acidic Deep Eutectic Solvent (DES) able to exploit a double activity, i. e., solvent and Brønsted Acid (BA) catalyst, avoiding the use of Volatile Organic Compounds (VOCs) as solvents and additional acid catalysts. By this way, we synthesized twenty‐five biindoles, including eighteen new compounds. The reactions run quickly under mild conditions by microwave heating at 70 °C, with yields ranging from good to very good. The reaction scope is rather broad. The medium demonstrated to be reusable at least five times with only a slight reduction in yields. Based on experimental evidence and previous literature findings, a plausible mechanism is proposed.

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