In this work, we present a continuous-wave yellow laser operating at 586.5nm based on self-Raman conversion in Nd:GdVO 4 . We report more than 4.2W CW and 5.5W instantaneous output at a 50% duty cycle regime. This is the highest CW power of a self-Raman laser to be reported so far. We also demonstrate the integration of this laser cavity into a console for applications in ophthalmology, and more specifically for retinal photocoagulation therapies.

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This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. This new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and denser, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm 2 , the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin. Close loop system for LED, UV based Optical system.Recently, the procedure to reduce the time of treatment by increasing the power density on corneal tissue, called accelerated procedure, has been investigated by doctors. Chew 3 presented that the same clinical results can be achieved by reducing the total time of UV exposure by increasing the power density to match with well-known energy dose of 5.4 J/cm 2 . He got reports of doctors who are practicing the accelerated procedure with their patients, and they are confident that this technique is worthy and efficient. Ronald R. Krueger 4 has shown that short time treatment can provide same corneal strengthening as lower powers over longer time periods, or there is no statistically significant biomechanical difference in both cases. John Mashal 5 , conducted an experiment of UV exposure to measure the effects on human endothelium cells, the deeper membrane in corneal tissue, which has to be preserved. He showed that viability of the cells did not show significant difference between low or high irradiance and was not cytotoxic to human endothelium

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