No abstract

Within the program of holographic renormalization, we discuss the computation of three-point correlation functions along RG flows. We illustrate the procedure in two simple cases. In an RG flow to the Coulomb branch of N = 4 SYM theory we derive a compact and finite expression for the three-point function of lowest CPO's dual to inert scalars. In the GPPZ flow, that captures some features of N = 1 SYM theory, we compute the three-point function with insertion of two inert scalars and one active scalar that mixes with the stress tensor. By amputating the external legs at the mass poles we extract the trilinear coupling of the corresponding superglueballs. Finally we outline the procedure for computing three-point functions with insertions of the stress tensor as well as of (broken) R-symmetry currents.

The prevalence of CD in the study group was 1:100 (1.0%; 95% CI: 0.5-1.8%): this indicates that CD is largely underdiagnosed in Carcare. Our results suggest that the low prevalence of CD observed in some regions is likely to be due to underdiagnosis.

Eleven patients with hemophilia BM were found out of a population of 66 patients with hemophilia B. Factor IX activity in the hemophilia BM varied between less than 1% and 1.6% of normal but factor IX antigen was normal or only slightly reduced in each instance. Thrombotest clotting time was variably prolonged and was not corrected by the addition of normal plasma. Thrombotest mixing experiments and dilution curve studies confirmed the presence of the inhibitor in every patient. There are at least two forms of hemophilia BM, a severe one and a mild one. In the first form, Thrombotest is severely prolonged (90-120 s). In the other, the prolongation is mild or moderate (60-80 s). A positive correlation exists between the antigen-activity difference (delta antigen-activity) and the prolongation of Thrombotest both in the propositi and in obligatory carriers. The criteria for the diagnosis of hemophilia BM are the following: prolonged PTT, prolonged Thrombotest, lack of correction of Thrombotest by the addition of normal plasma while PTT is fully corrected. The lack of correction of Thrombotest in the presence of a full correction of PTT, is the unique clotting feature.

This work involved human subjects or animals in its research. Approval of all ethical and experimental procedures and protocols was granted by the Ethics Committee of Campus Bio-Medico University of Rome (11/05/2021), and performed in line with the Declaration of Helsinki.