No abstract

Highlights d Metabolite channel of mitochondrial outer membrane promotes protein import d Porin interacts with carrier precursors accumulated in the intermembrane space d Porin recruits the carrier translocase of the inner mitochondrial membrane d Dual role of porin as metabolite channel and as coupling factor in protein import

Highlights d Invasive tumor borders and cells proximal to vessels show upregulated Rac1 activity d Rac1 inhibition enhances tumor cell vulnerability during fluidflow shear stress d Live in vivo imaging of Rac1 activity guides optimal disease progression targeting d Rac1 inhibition reduces intratumoral movement and lung metastasis