SUMMARY BackgroundThe current standard of care in proton pump inhibitor failure is to double the proton pump inhibitor dose, despite limited therapeutic gain.

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After 40 hr storage at 2 °C, the tensile strength of “rested” king salmon (Oncorhynchus tshawytscha) “white” muscle was 2.7 times that of the “exhausted” muscle with the “rested” muscle retaining its immediate post‐capture strength. A combination of behavioral conditioning, conservative handling practices and chemical anaesthesia (AQUI‐STM) was used to minimize the extent of pre‐mortem exercise and thereby provide “rested” fish. Postmortem electrical stimulation of the “rested” animals was used to produce “exhausted” muscle. This study highlights the importance of reducing pre‐harvest exercise in the production of high quality fish muscle.

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Isometric rigorometry was used to study rigor tensions in "rested", "partially exercised" and "exhausted" chinook salmon (Oncorhynchus tshawytscha) white muscle at the pre-mortem acclimated temperature. Conservative handling and anaesthesia (AQUI-S TM ) minimized pre-mortem exercise and provided "rested" fish. Post-mortem electrical stimulation produced "partially exercised" (180 contractions) and "exhausted" (360 contractions) muscle. A "relaxation" stress that decreased with increasing exercise was measured. The amplitude of the "relaxation" and contraction stress was the same for each treatment (F 2,12 = 0.24; p=0.79). Rigor contraction onset coincided with an intra-muscular pH of 6.6 in each treatment (F 2,12 =0.28, p=0.76). Contraction stress abatement coincided with an "ultimate" pH of 6.2 in each of the treatments (F 1,12 =0.05; p=0.83).