Introduction:Minthostachys mollis Griseb belonging to the genus Minthostachys known commonly as Muña, a native of Colombia, Ecuador, Peru and Venezuela. Objective: To evaluate the effect of the antioxidant activity of the essential oil of Minthostachys mollis G in a type sausage meat product. Materials and methods: Determined the composition chemical by chromatography of gases/spectrometer of mass, the activity antioxidant is evaluated by the method DPPH. In addition, we 3992 Clemente Granados-Conde et al.studied the effects of essential oil on lipid oxidation of a meat product type sausage, analyzing the formation of 2-thiobarbituric acid reactive substances, as indicators of oxidation. Results: Found high levels of oxygenated monoterpenes (Thymol and carvacrol); the antioxidant activity of essential oil Minthostachys mollis (IC50 70,5±0,33 μg/mL). Demonstrating that the AE has the capacity of inhibiting the process oxidative of a matrix food as the sausage. Conclusions: It is established that the AE of M. mollis is a promising natural antioxidant, which can be used in the food industry as a possible substitute for synthetic antioxidants.