Completing the cycle: Cobalt complexes I and II were found to catalyze intramolecular alkyl Heck‐type coupling reactions of alkyl iodides to alkenes upon irradiation with visible light in the presence of a tertiary amine base. The use of base is key to the catalytic turnover. The compatibility of the method with a broad range of functional groups opens opportunities for synthesis.
Unverzichtbare Base: Die Cobaltkomplexe I und II katalysieren intramolekulare Kupplungen vom Alkyl‐Heck‐Typ zwischen Alkyliodiden und Alkenen bei der Bestrahlung mit sichtbarem Licht, wenn ein tertiäres Amin als Base zugegen ist. Die Methode ist mit einer großen Bandbreite an funktionellen Gruppen kompatibel, was auf vielseitigen Einsatz in der Synthese hoffen lässt.
A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.
A novel method using cobalt catalysts (I) and irradiation with blue LEDs allows the intramolecular Heck‐type coupling yield the corresponding cyclic products under mild conditions.
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