The Local tourism products are profitable approach for local citizens of each town to generate employment prospects. One Town One Product is a government campaign that promotes regional pride, indigenous product rediscovery, entrepreneurship, and public-private partnerships as fundamental elements for Micro, Small, and Medium Enterprises (MSMEs).The principal aim of the paper is to evaluate the key success factors and entrepreneurial orientation of tourism entrepreneurs through One Town One Product in the province of Camarines Sur. It assessed the DTI-Registered OTOP beneficiaries particularly its demographic profile; key success factors in terms of entrepreneur, enterprise, and network/stakeholders; also, the entrepreneurial orientation in terms of innovativeness, proactiveness, risk-taking, competitive aggressiveness, and autonomy. The data was collected from the 362 OTOP employees in Camarines Sur through a questionnaire. To demonstrate the considerable association between the respondents' profile and their entrepreneurial orientation, a descriptive method was used. Given the results, there is a high priority on small-scale business in terms of entrepreneurs in Camarines Sur who are willing to expand their entrepreneurial skills and abilities. These skills and abilities include innovativeness, proactiveness, competitive aggressiveness, risk taking, as well as autonomy which makes a certain tourism souvenir business strive.