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HIS STL~DY was prompted by the demon-T stration that cancer cells exfoliate into body fluids, including blood and lymph, in a very high percentage of patient~,l-~, 6-s, 14915 even those with early operable lesions.2, 4, 6 , 8 , 1 0 T h e high frequency of cancer cell contamination in casual specimens indicates that not all disseminated cancer cells develop into metastases and suggests that in many patients none produce metastatic lesions.This study was designed to test directly the autotransplantability of human cancer cells, on the assumption that subcutaneous autotransplantation would serve as a model of natural metastases, and to probe for possible explanations of the presumed failure of many disseminating cancer cells to implant and grow.Although the data are still preliminary, it is felt that they are significant and of sufficient interest to merit presentation at this time. MATERIALS AND METHODST h e patients were of 2 general categories:Chemotherapy Service patients with extensive recurrent or disseminated cancer for whom there remained no established method of treatment and who had tumor accessible to biopsy, and Gynecology Service patients who had had an exploratory or ablative operation but in whom the disease was not completely resectable or in whom the distribution of disease and type of operation was such that the probability of cure was extremely low. Most patients were interviewed before the procedure and inflormed of the experimental nature and general purpose of the study and the details of the procedure.

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