Abstract:Introduction: diabetic foot is a major economic problem, and its management has not always been performed in a most cost effective way. This study on diabetic foot infection aimed at comparison of the effect of bee honey with another concentrated carbohydrate solution like glycerin and with a group using betadine and saline. Patients, Materials and Methods: The patients were divided into three groups; Group A: dressing with bee honey, Group B: dressing with glycerin magnesia and Group C: represented the control group dressed with Betadine and Saline. Results: We observed that the tested materials had positive effects on diabetic foot infections but honey surpassed all by reducing the debridement times and the load of infecting organisms. Conclusion: Local wound care plays a good role when topically applied to treat diabetic foot wounds. Honey seems effective in combating infection and helps wound healing.