Electron acceleration by laser-driven plasma waves 1,2 is capable of producing ultra-relativistic, quasi-monoenergetic electron bunches 3-5 with orders of magnitude higher accelerating gradients and much shorter electron pulses than state-of-the-art radio-frequency accelerators. Recent developments have shown peak energies reaching into the GeV range 6 and improved stability and control over the energy spectrum and charge 7 . Future applications, such as the development of laboratory X-ray sources with unprecedented peak brilliance 8,9 or ultrafast time-resolved measurements 10 critically rely on a temporal characterization of the acceleration process and the electron bunch. Here, we report the first real-time observation of the accelerated electron pulse and the accelerating plasma wave. Our time-resolved study allows a single-shot measurement of the 5.8 +1.9 −2.1 fs electron bunch duration full-width at half-maximum (2.5 +0.8 −0.9 fs root mean square) as well as the plasma wave with a density-dependent period of 12-22 fs and reveals the evolution of the bunch, its position in the surrounding plasma wave and the wake dynamics. The results afford promise for brilliant, sub-ångström-wavelength ultrafast electron and photon sources for diffraction imaging with atomic resolution in space and time 11 .The recent development in laser wakefield acceleration (LWFA) is made feasible by transverse breaking of the plasma wave 12 , which results in self-injection and trapping of electrons in the accelerating structure 2,13,14 . Whereas beam parameters such as the energy spectrum, accelerated charge, beam divergence and pointing are now being measured routinely with methods adopted from conventional accelerator technology, the duration of electron bunches arising from LWFA has so far defied accurate determination. Bunch duration measurements up to now have relied on techniques using THz radiation emitted by the electrons, yielding upper limits for the electron pulse length corresponding to the temporal resolution of ≥30 fs (refs 15-18). The plasma wave has been observed so far in single-shot, yet time-integrating schemes 19,20 . Thus, the measurements were incapable of providing insight into the relevant plasma wave dynamics and of timing the accelerated electron bunch with respect to the plasma wave.In this work we present snapshots of the magnetic field generated by the accelerated electron bunch and-simultaneously-of the plasma wave by the combination of two techniques: time-resolved polarimetry 21,22 and plasma shadowgraphy 23 . The novelty in our experimental investigation is the few-cycle duration of our laser pulses, which is even shorter than half of the plasma period. This, in combination with a high spatial resolution, allows

We present few-femtosecond shadowgraphic snapshots taken during the non-linear evolution of the plasma wave in a laser wakefield accelerator with transverse synchronized few-cycle probe pulses. These snapshots can be directly associated with the electron density distribution within the plasma wave and give quantitative information about its size and shape. Our results show that self-injection of electrons into the first plasma wave period is induced by a lengthening of the first plasma period. Three dimensional particle in cell simulations support our observations.Laser-wakefield accelerators (LWFA) operating in the 'bubble'-regime [1] can generate quasimonoenergetic multigigaelectronvolt electron beams [2,3] with femtosecond duration [4,5] and micrometer dimensions [6,7]. These beams are produced by accelerating electrons in laser-driven plasma waves over centimeter distances. They have the potential to be compact alternatives to conventional accelerators [8]. In a LWFA, the short driving laser pulse displaces plasma electrons from the stationary background ions. The generated space charge fields cause the electrons to oscillate and form a plasma wave in the laser's wake. This wave follows the laser at almost c, the speed of light; for low amplitude it has a wavelength ofwhere n e is the electron density of the plasma. At high amplitude, electrons from the background can be injected into the wake and accelerated, producing monoenergetic electron pulses [9][10][11]. Significant progress has been made regarding achievable peak energy [3], beam stability [12] and the generation of bright X-ray pulses [13][14][15]. Until now, most of our knowledge about the dynamics of the self-injection process has been derived from detailed particle-in-cell (PIC) simulations. These simulations show that self-focusing [16] and pulse compression [17] play a vital role in increasing the laser pulse intensity prior to injection. Furthermore, simulations indicate that self-injection of electrons is associated with a dynamic lengthening of the first plasma wave's period (the 'bubble'). This lengthening can be driven by changes of the electric field structure inside the plasma wave caused by the injected electrons [18]. In contrast, the lengthening may also be due to an intensity amplification of the laser pulse caused by the non-linear evolution of the plasma wave [19,20] or due to a local increase in intensity caused by two colliding pulses [21]. In these latter scenarios, injection is a consequence of the lengthening of the bubble. However, experimental insight into these processes is extremely challenging due to the small spatial and temporal scales of a LWFA.The plasma wave, a variation in the electron density, has an associated refractive index profile which can be detected using longitudinal [22][23][24] or transverse probes [5]. Longitudinal probes cannot measure the rapid and dynamic evolution of the plasma wave that occurs in nonlinear wakefield accelerators and suffer from the strong refraction caused by the steep refractive ...

We investigate the properties of a laser-plasma electron accelerator as a bright source of keV x-ray radiation. During the interaction, the electrons undergo betatron oscillations and from the carefully measured x-ray spectrum the oscillation amplitude of the electrons can be deduced which decreases with increasing electron energies. From the oscillation amplitude and the independently measured x-ray source size of (1.8±0.3) μm we are able to estimate the electron bunch diameter to be (1.6±0.3) μm.

The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo experiments with laser-driven electron pulses by utilization of a small tumour model on the mouse ear for the human squamous cell carcinoma model FaDu. The already established in vitro irradiation technology at the laser system JETI was further enhanced for 3D tumour irradiation in vivo in terms of beam transport, beam monitoring, dose delivery and dosimetry in order to precisely apply a prescribed dose to each tumour in full-scale radiobiological experiments. Tumour growth delay was determined after irradiation with doses of 3 and 6 Gy by laser-accelerated electrons. Reference irradiation was performed with continuous electron beams at a clinical linear accelerator in order to both validate the dedicated dosimetry employed for laser-accelerated JETI electrons and above all review the biological results. No significant difference in radiation-induced tumour growth delay was revealed for the two investigated electron beams. These data provide evidence that the ultra-high dose rate generated by laser acceleration does not impact the biological effectiveness of the particles.

Laser-plasma particle accelerators could provide more compact sources of high-energy radiation than conventional accelerators. Moreover, because they deliver radiation in femtosecond pulses, they could improve the time resolution of X-ray absorption techniques. Here we show that we can measure and control the polarization of ultra-short, broad-band keV photon pulses emitted from a laser-plasma-based betatron source. The electron trajectories and hence the polarization of the emitted X-rays are experimentally controlled by the pulse-front tilt of the driving laser pulses. Particle-in-cell simulations show that an asymmetric plasma wave can be driven by a tilted pulse front and a non-symmetric intensity distribution of the focal spot. Both lead to a notable off-axis electron injection followed by collective electron–betatron oscillations. We expect that our method for an all-optical steering is not only useful for plasma-based X-ray sources but also has significance for future laser-based particle accelerators.